Recombinant Human Deleted in azoospermia protein 2 (DAZ2)

Uniprot Id

Q13117

Target Species

Human

Target Name

DAZ2

Target Full Name

Deleted in azoospermia protein 2

Target Function

RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.

Target Involvement

Spermatogenic failure Y-linked 2 (SPGFY2)

Target Subcellular Location

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Target Protein Families

RRM DAZ family

Target Tissue Specificity

Testis specific.

Target Synonyms

DAZ2; DAZ2_HUMAN; DAZ3; Deleted in azoospermia 2; Deleted in azoospermia protein 2; Deleted in azoospermia protein 3; MGC126442; pDP1678

Target Background

This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms.