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The antibody against NELL2 was raised in rabbit using the Recombinant Human Protein kinase C-binding protein NELL2 protein (511-637AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against NELL2 was raised in rabbit using the Recombinant Human Protein kinase C-binding protein NELL2 protein (511-637AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human testis tissue using NELL2 Antibody at dilution of 1:100
| Cat.No | ADC-09523A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NELL2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein kinase C-binding protein NELL2 protein (511-637AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99435 |
Uniprot Id
Q99435
Target Species
Human
Target Name
NELL2
Target Full Name
Protein kinase C-binding protein NELL2
Target Function
Required for neuron survival through the modulation of MAPK pathways. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty.
Target Subcellular Location
Secreted.
Target Synonyms
A330108N19Rik; Mel91; MEL91 protein; NEL like 2 (chicken); NEL-like protein 2; Nel-related protein 2; NELL2; NELL2_HUMAN; Neural epidermal growth factor like 2; NRP2; Protein kinase C-binding protein NELL2; R75516
Target Background
The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis.
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