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| Cat.No | ACP17878 | Target Name | MMRN1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13201 |
|---|
Uniprot Id
Q13201
Target Species
Human
Target Name
MMRN1
Target Full Name
Multimerin-1
Target Function
Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.
Target Involvement
Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec).
Target Subcellular Location
Secreted.
Target Tissue Specificity
Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium
Target Synonyms
155 kDa platelet multimerin; ECM; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN 4; EMILIN-4; EMILIN4; Endothelial cell multimerin 1; Endothelial cell multimerin; Glycoprotein Ia*; GlycoproteinIa*; GPIa*; MMRN 1; MMRN; MMRN1; MMRN1_HUMAN; Multimerin 1; Multimerin1; p-155; p155
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