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| Cat.No | ACP17901 | Target Name | KYNU |
|---|---|---|---|
| Target Synonyms | kynU; KYNU_HUMAN; kynureninase (L-kynurenine hydrolase); Kynureninase; L-kynurenine hydrolase | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-465aa |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q16719 |
|---|
Uniprot Id
Q16719
Target Species
Human
Target Name
KYNU
Target Full Name
Kynureninase
Target Function
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Target Involvement
Hydroxykynureninuria (HYXKY); Vertebral, cardiac, renal, and limb defects syndrome 2 (VCRL2)
Target Subcellular Location
Cytoplasm, cytosol.
Target Protein Families
Kynureninase family
Target Tissue Specificity
Expressed in all tissues tested (heart, brain placenta, lung, liver, skeletal muscle, kidney and pancreas). Highest levels found in placenta, liver and lung. Expressed in all brain regions.
Target Research Area
Signal Transduction
Target Synonyms
kynU; KYNU_HUMAN; kynureninase (L-kynurenine hydrolase); Kynureninase; L-kynurenine hydrolase
Target Background
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
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