Recombinant Human Syntaxin-binding protein 2 (STXBP2)

Uniprot Id

Q15833

Target Species

Human

Target Name

STXBP2

Target Full Name

Syntaxin-binding protein 2

Target Function

Involved in intracellular vesicle trafficking and vesicle fusion with membranes. Contributes to the granule exocytosis machinery through interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that regulate membrane fusion. Regulates cytotoxic granule exocytosis in natural killer (NK) cells.

Target Involvement

Familial hemophagocytic lymphohistiocytosis 5 (FHL5)

Target Protein Families

STXBP/unc-18/SEC1 family

Target Tissue Specificity

Placenta, lung, liver, kidney and pancreas, as well as in peripheral blood lymphocytes.

Target Synonyms

FHL5; Hunc18b; MUNC18 2; pp10122; Protein unc-18 homolog 2; Protein unc-18 homolog B; STXB2_HUMAN; Stxbp2; syntaxin binding protein 2; Syntaxin-binding protein 2; Unc-18B; UNC18 2; Unc18-2; UNC18B

Target Background

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.