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The antibody against MICU2 was raised in rabbit using the Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against MICU2 was raised in rabbit using the Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human colon cancer using MICU2 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung cancer using MICU2 Antibody at dilution of 1:1002
| Cat.No | ADC-09559A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | MICU2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Calcium uptake protein 2, mitochondrial protein (26-247AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IYU8 |
Uniprot Id
Q8IYU8
Target Species
Human
Target Name
MICU2
Target Full Name
Calcium uptake protein 2, mitochondrial
Target Function
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, depending on the concentration of calcium. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting calcium, avoiding energy dissipation and cell-death triggering.
Target Subcellular Location
Mitochondrion intermembrane space.
Target Protein Families
MICU1 family, MICU2 subfamily
Target Synonyms
1110008L20Rik; EF hand domain containing family member A1; EF hand domain family A1; EF hand domain family member A1; EF-hand domain-containing family member A1; EFHA1; EFHA1 EF hand domain family member A1; EFHA1_HUMAN; FLJ25016; FLJ34588; Smhs2 homolog
Target Background
Enables protein heterodimerization activity. Involved in calcium import into the mitochondrion and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of uniplex complex.
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