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| Cat.No | ACP18720 | Target Name | BLMH |
|---|---|---|---|
| Target Synonyms | BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BLMH_HUMAN; BMH; EC 3.4.22.40 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-455 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q13867 |
|---|
Uniprot Id
Q13867
Target Species
Human
Target Name
BLMH
Target Full Name
Bleomycin hydrolase
Target Function
The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity.
Target Subcellular Location
Cytoplasm. Cytoplasmic granule.
Target Protein Families
Peptidase C1 family
Target Synonyms
BH; Bleomycin hydrolase; BLM hydrolase; BLMH; BLMH_HUMAN; BMH; EC 3.4.22.40
Target Background
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however, the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.
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