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| Cat.No | ACP18731 | Target Name | CDSN |
|---|---|---|---|
| Target Synonyms | AI747712; CDSN; CDSN_HUMAN; Corneodesmosin; D6S586E; DADB-141O4.5; Differentiated keratinocyte S protein; HTSS; S; S protein | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 33-529 |
| Protein Length | Full Length of Mature Protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q15517 |
|---|
Uniprot Id
Q15517
Target Species
Human
Target Name
CDSN
Target Full Name
Corneodesmosin
Target Function
Important for the epidermal barrier integrity.
Target Involvement
Hypotrichosis 2 (HYPT2); Peeling skin syndrome 1 (PSS1)
Target Subcellular Location
Secreted. Note=Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
Target Tissue Specificity
Exclusively expressed in skin.
Target Synonyms
AI747712; CDSN; CDSN_HUMAN; Corneodesmosin; D6S586E; DADB-141O4.5; Differentiated keratinocyte S protein; HTSS; S; S protein
Target Background
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
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