Recombinant Human Ancient ubiquitous protein 1 (AUP1), Truncated

Uniprot Id

Q9Y679

Target Species

Human

Target Name

AUP1

Target Full Name

Lipid droplet-regulating VLDL assembly factor AUP1

Target Function

Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB.; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.

Target Subcellular Location

Endoplasmic reticulum membrane; Peripheral membrane protein. Lipid droplet.; Cytoplasmic vesicle, autophagosome.

Target Protein Families

AUP1 family

Target Tissue Specificity

Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.

Target Synonyms

AA589454; Ancient ubiquitous protein 1; AUP 1; aup1; AUP1_HUMAN