Recombinant Human Carboxypeptidase A4 (CPA4)

Uniprot Id

Q9UI42

Target Species

Human

Target Name

CPA4

Target Full Name

Carboxypeptidase A4

Target Function

Metalloprotease that could be involved in the histone hyperacetylation pathway. Releases a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase M14 family

Target Tissue Specificity

Fetal expression in the adrenal gland, brain, heart, intestine, kidney, liver and lung. Except for fetal brain that shows no imprinting, expression was found preferentially from the maternal allele.

Target Synonyms

Carboxypeptidase A3; Carboxypeptidase A4; CBPA4_HUMAN; CPA3 ; Cpa4

Target Background

This gene is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness.