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| Cat.No | ACP18997 | Target Name | ESRP2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-727 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9H6T0 |
|---|
Uniprot Id
Q9H6T0
Target Species
Human
Target Name
ESRP2
Target Full Name
Epithelial splicing regulatory protein 2
Target Function
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Target Subcellular Location
Nucleus.
Target Protein Families
ESRP family
Target Tissue Specificity
Epithelial cell-specific.
Target Synonyms
Epithelial splicing regulatory protein 2; ESRP 2; ESRP2; ESRP2_HUMAN; FLJ21918; FLJ22248; RBM35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA binding protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B
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