Recombinant Human Tenomodulin (TNMD), Truncated

Uniprot Id

Q9H2S6

Target Species

Human

Target Name

TNMD

Target Full Name

Tenomodulin

Target Function

May be an angiogenesis inhibitor.

Target Subcellular Location

[Isoform 1]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 2]: Membrane; Single-pass type II membrane protein. Nucleus envelope.; [Isoform 3]: Cytoplasm.

Target Protein Families

Chondromodulin-1 family

Target Tissue Specificity

Highly expressed in hypovascular connective tissues such as tendons. Has also strong expression in adipose tissue.

Target Synonyms

BRICD4; BRICHOS domain containing 4; CHM1 LIKE; ChM1L; Chondromodulin I like; Chondromodulin I like protein; Chondromodulin-1-like protein; Chondromodulin-I-like protein; hChM1L; hTeM; Myodulin; TeM; Tendin; Tenomodulin; Tenomodulin protein; Tnmd; TNMD_HUMAN; UNQ771/PRO1565

Target Background

This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated.