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The antibody against TIE1 was raised in rabbit using the Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TIE1 was raised in rabbit using the Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using TIE1 Antibody at dilution of 1:100
Immunofluorescent analysis of A549 cells using TIE1 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-09629A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIE1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Tyrosine-protein kinase receptor Tie-1 protein (217-328AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P35590 |
Uniprot Id
P35590
Target Species
Human
Target Name
TIE1
Target Full Name
Tyrosine-protein kinase receptor Tie-1
Target Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
Target Tissue Specificity
Specifically expressed in developing vascular endothelial cells.
Target Synonyms
JKT 14; JTK14; TIE; Tie1; TIE1_HUMAN; Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains; Tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine protein kinase receptor Tie 1; Tyrosine-protein kinase receptor Tie-1
Target Background
This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
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