Recombinant Human mRNA-capping enzyme (RNGTT)

Uniprot Id

O60942

Target Species

Human

Target Name

RNGTT

Target Full Name

mRNA-capping enzyme

Target Function

Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.

Target Subcellular Location

Nucleus.

Target Protein Families

Non-receptor class of the protein-tyrosine phosphatase family; Eukaryotic GTase family

Target Tissue Specificity

Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Target Synonyms

CAP1A; GTase; GTP--RNA guanylyltransferase; hCAP; HCAP1; HcE; HCE1; MCE1; MCE1_HUMAN; mRNA 5''-triphosphatase; mRNA capping enzyme; mRNA guanyltransferase; mRNA guanylyltransferase; Polynucleotide 5' trisphosphatase; RNA guanylyltransferase and 5' phosphatase; RNGTT; TPase

Target Background

Enables mRNA guanylyltransferase activity and triphosphatase activity. Involved in 7-methylguanosine mRNA capping. Predicted to be located in nucleoplasm.