Recombinant Human Bone morphogenetic protein 15 (BMP15)

Uniprot Id

O95972

Target Species

Human

Target Name

BMP15

Target Full Name

Bone morphogenetic protein 15

Target Function

May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.

Target Involvement

Ovarian dysgenesis 2 (ODG2); Premature ovarian failure 4 (POF4)

Target Subcellular Location

Secreted.

Target Protein Families

TGF-beta family

Target Research Area

Developmental Biology

Target Synonyms

BMP 15; BMP-15; BMP15; BMP15_HUMAN; Bone morphogenetic protein 15; GDF 9B; GDF-9B; GDF9B; Growth/differentiation factor 9B; ODG2 ; POF4

Target Background

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure.