Recombinant Human Krueppel-like factor 8 (KLF8)

Uniprot Id

O95600

Target Species

Human

Target Name

KLF8

Target Full Name

Krueppel-like factor 8

Target Function

Transcriptional repressor and activator. Binds to CACCC-boxes promoter elements. Also binds the GT-box of cyclin D1 promoter and mediates cell cycle progression at G(1) phase as a downstream target of focal adhesion kinase (FAK).

Target Subcellular Location

Nucleus.

Target Protein Families

Sp1 C2H2-type zinc-finger protein family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Basic krueppel-like factor 3; BKLF3; DXS741; KLF8; KLF8_HUMAN; Krueppel-like factor 8; Kruppel like factor 8; MGC138314; Zinc finger protein 741; ZNF741

Target Background

This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.