Recombinant Human Annexin A9 (ANXA9)

Uniprot Id

O76027

Target Species

Human

Target Name

ANXA9

Target Full Name

Annexin A9

Target Function

Low affinity receptor for acetylcholine known to be targeted by disease-causing pemphigus vulgaris antibodies in keratinocytes.

Target Protein Families

Annexin family

Target Tissue Specificity

Expressed in the stratified squamous skin epithelium, but not in epithelia of other types (at protein level).

Target Research Area

Signal Transduction

Target Synonyms

annexin 31; annexin 31; formerly; Annexin A9; Annexin XXXI; Annexin-31; Annexin-9; ANX31; ANX31; formerly; ANXA9; ANXA9_HUMAN; Pemphaxin

Target Background

The annexins are a family of calcium-dependent phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.