Recombinant Human Metastasis-associated protein MTA2 (MTA2)

Uniprot Id

O94776

Target Species

Human

Target Name

MTA2

Target Full Name

Metastasis-associated protein MTA2

Target Function

May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Widely expressed.

Target Synonyms

DKFZp686F2281; Mata1l1; Metastasis associated 1 family member 2; Metastasis associated 1 like 1; Metastasis associated gene 1 like 1; Metastasis associated gene family member 2; Metastasis associated protein 2; Metastasis associated protein MTA 2; Metastasis associated protein MTA2; Metastasis-associated 1-like 1; Metastasis-associated protein MTA2; Mmta2; MTA1 L1 protein; MTA1-L1 protein; MTA1L1; MTA2; MTA2_HUMAN; p53 target protein in deacetylase complex; PID

Target Background

This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.