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Recombinant Human Disabled homolog 1 (DAB1)

ACP21069

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Specifications

Cat.No	ACP21069	Target Name	DAB1
Target Synonyms	Dab 1; Dab reelin signal transducer 1; Dab; reelin signal transducer; homolog 1 (Drosophila); Dab1; DAB1_HUMAN; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-588
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O75553

Background Information

Uniprot Id

O75553
Target Species

Human
Target Name

DAB1
Target Full Name

Disabled homolog 1
Target Function

Adapter molecule functioning in neural development. May regulate SIAH1 activity.
Target Involvement

Spinocerebellar ataxia 37 (SCA37)
Target Tissue Specificity

Mainly expressed in brain.
Target Synonyms

Dab 1; Dab reelin signal transducer 1; Dab; reelin signal transducer; homolog 1 (Drosophila); Dab1; DAB1_HUMAN; Disabled homolog 1; Disabled homolog 1 Drosophila; Scm; Scr; Scrambler; Yot; Yotari
Target Background

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.

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Recombinant Human Disabled homolog 1 (DAB1)

Specifications

Immunogen Information

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