Recombinant Human RING finger protein 113A (RNF113A)

ACP21369

Number

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Specifications

Cat.No	ACP21369	Target Name	RNF113A
Target Synonyms	RNF113A; RNF113; ZNF183; E3 ubiquitin-protein ligase RNF113A; EC 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	2-343
Protein Length	Full Length of Mature Protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	O15541

Background Information

Uniprot Id

O15541
Target Species

Human
Target Name

RNF113A
Target Full Name

E3 ubiquitin-protein ligase RNF113A
Target Function

Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling.
Target Involvement

Trichothiodystrophy 5, non-photosensitive (TTD5)
Target Subcellular Location

Nucleus. Nucleus speckle.
Target Tissue Specificity

Ubiquitous.
Target Synonyms

RNF113A; RNF113; ZNF183; E3 ubiquitin-protein ligase RNF113A; EC 2.3.2.27; Cwc24 homolog; RING finger protein 113A; Zinc finger protein 183

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Recombinant Human RING finger protein 113A (RNF113A)

Specifications

Immunogen Information

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