Recombinant Human Protein phosphatase 1D (PPM1D)

Cat.No	ACP21381	Target Name	PPM1D
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-605	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP21381

Target Name

PPM1D

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-605

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O15297

Background Information

Uniprot Id

O15297
Target Species

Human
Target Name

PPM1D
Target Full Name

Protein phosphatase 1D
Target Function

Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity.
Target Involvement

Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold (IDDGIP); Breast cancer (BC); Ovarian cancer (OC)
Target Subcellular Location

Nucleus. Cytoplasm, cytosol.
Target Protein Families

PP2C family
Target Tissue Specificity

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.
Target Synonyms

EC 3.1.3.16; p53 induced protein phosphatase 1; p53-induced protein phosphatase 1; PP2C delta; PP2C-delta; PP2CD; Ppm1d; PPM1D_HUMAN; Protein phosphatase 1D; protein phosphatase 1D magnesium-dependent delta isoform ; Protein phosphatase 2C delta isoform; Protein phosphatase 2C isoform delta; Protein phosphatase magnesium dependent 1 delta; Protein phosphatase magnesium-dependent 1 delta; Protein phosphatase Mg2+/Mn2+ dependent 1D; Protein phosphatase Wip1; Wild type p53 induced phosphatase 1; WIP 1; WIP1
Target Background

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

Recombinant Human Protein phosphatase 1D (PPM1D)

Specifications

Immunogen Information

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