Recombinant Human ATP-dependent RNA helicase DDX39A (DDX39A)

Uniprot Id

O00148

Target Species

Human

Target Name

DDX39A

Target Full Name

ATP-dependent RNA helicase DDX39A

Target Function

Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus.

Target Subcellular Location

Nucleus. Cytoplasm. Note=Can translocate to the cytoplasm in the presence of MX1.

Target Protein Families

DEAD box helicase family, DECD subfamily

Target Tissue Specificity

Detected in testis, and at lower levels in brain, kidney, lung, thymus, spleen and salivary gland.

Target Synonyms

DDX39A; DDX39; ATP-dependent RNA helicase DDX39A; EC 3.6.4.13; DEAD box protein 39; Nuclear RNA helicase URH49

Target Background

This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.