Recombinant Human Coagulation factor X (F10)

Uniprot Id

P00742

Target Species

Human

Target Name

F10

Target Full Name

Coagulation factor X

Target Function

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

Target Involvement

Factor X deficiency (FA10D)

Target Subcellular Location

Secreted.

Target Protein Families

Peptidase S1 family

Target Tissue Specificity

Plasma; synthesized in the liver.

Target Research Area

Signal Transduction

Target Synonyms

Activated factor Xa heavy chain; Coagulation factor X ; F10; FA10_HUMAN; FX ; FXA; Prothrombinase ; Stuart factor; Stuart Prower factor; Stuart-Prower factor

Target Background

This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides.