Recombinant Human Matrix Gla protein (MGP)

Uniprot Id

P08493

Target Species

Human

Target Name

MGP

Target Full Name

Matrix Gla protein

Target Function

Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.

Target Involvement

Keutel syndrome (KTLS)

Target Subcellular Location

Secreted.

Target Protein Families

Osteocalcin/matrix Gla protein family

Target Research Area

Developmental Biology, Signal Transduction

Target Synonyms

Cell growth inhibiting gene 36 protein; Cell growth-inhibiting gene 36 protein; GAMMA-CARBOXYGLUTAMIC ACID PROTEIN, MATRIX; GIG36; Matrix Gla protein; MGLAP; MGP; MGP_HUMAN; NTI

Target Background

This gene encodes a member of the osteocalcin/matrix Gla family of proteins. The encoded vitamin K-dependent protein is secreted by chondrocytes and vascular smooth muscle cells, and functions as a physiological inhibitor of ectopic tissue calcification. Carboxylation status of the encoded protein is associated with calcification of the vasculature in human patients with cardiovascular disease and calcification of the synovial membranes in osteoarthritis patients. Mutations in this gene cause Keutel syndrome in human patients, which is characterized by abnormal cartilage calcification, peripheral pulmonary stenosis and facial hypoplasia.