Recombinant Human C-terminal-binding protein 2 (CTBP2)

Uniprot Id

P56545

Target Species

Human

Target Name

CTBP2

Target Full Name

C-terminal-binding protein 2

Target Function

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation.; Isoform 2 probably acts as a scaffold for specialized synapses.

Target Subcellular Location

Nucleus. Cell junction, synapse.

Target Protein Families

D-isomer specific 2-hydroxyacid dehydrogenase family

Target Tissue Specificity

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Target Synonyms

C terminal binding protein 2; C-terminal-binding protein 2; CtBP2; CTBP2_HUMAN; ribeye

Target Background

This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene.