Recombinant Human Protein Wnt-3a (WNT3A)

Uniprot Id

P56704

Target Species

Human

Target Name

WNT3A

Target Full Name

Protein Wnt-3a

Target Function

Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube. Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro).

Target Subcellular Location

Secreted, extracellular space, extracellular matrix. Secreted.

Target Protein Families

Wnt family

Target Tissue Specificity

Moderately expressed in placenta and at low levels in adult lung, spleen, and prostate.

Target Research Area

Developmental Biology, Signal Transduction

Target Synonyms

Protein Wnt 3a Precursor; Protein Wnt-3a; Wingless type MMTV integration site family member 3A; Wnt 3a; wnt3a; WNT3A protein; WNT3A_HUMAN

Target Background

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 96% amino acid identity to mouse Wnt3A protein, and 84% to human WNT3 protein, another WNT gene product. This gene is clustered with WNT14 gene, another family member, in chromosome 1q42 region.