Recombinant Human Homeobox protein goosecoid (GSC)

Uniprot Id

P56915

Target Species

Human

Target Name

GSC

Target Full Name

Homeobox protein goosecoid

Target Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring. Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.

Target Involvement

Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS)

Target Subcellular Location

Nucleus.

Target Protein Families

Paired homeobox family, Bicoid subfamily

Target Synonyms

Goosecoid; goosecoid homeobox; GSC; GSC_HUMAN; Homeobox protein goosecoid

Target Background

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis.