Recombinant Human Plexin-A3 (PLXNA3), Truncated

Uniprot Id

P51805

Target Species

Human

Target Name

PLXNA3

Target Full Name

Plexin-A3

Target Function

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Plexin family

Target Synonyms

PLXNA3; PLXN4; SEX; Plexin-A3; Plexin-4; Semaphorin receptor SEX

Target Background

This gene encodes a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system. This gene may be associated with tumor progression.