Recombinant Human Stanniocalcin-1 (STC1)

Uniprot Id

P52823

Target Species

Human

Target Name

STC1

Target Full Name

Stanniocalcin-1

Target Function

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Target Subcellular Location

Secreted.

Target Protein Families

Stanniocalcin family

Target Tissue Specificity

Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, l

Target Research Area

Metabolism, Signal Transduction

Target Synonyms

Stanniocalcin 1; Stanniocalcin; Stanniocalcin-1; STC; STC-1; Stc1; STC1_HUMAN

Target Background

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers.