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Recombinant Human Neural retina-specific leucine zipper protein (NRL)

ACP22942

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Specifications

Cat.No	ACP22942	Target Name	NRL
Target Synonyms	D14S46E; Neural retina-specific leucine zipper protein; Neural retinal specific leucine zipper; NRL; NRL MAF; NRL_HUMAN; RP27	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-237
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	P54845

Background Information

Uniprot Id

P54845
Target Species

Human
Target Name

NRL
Target Full Name

Neural retina-specific leucine zipper protein
Target Function

Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Functions also as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds in a sequence-specific manner to the rhodopsin promoter.
Target Involvement

Retinitis pigmentosa 27 (RP27); Retinal degeneration autosomal recessive clumped pigment type (RDCP)
Target Subcellular Location

Cytoplasm. Nucleus.
Target Protein Families

BZIP family
Target Tissue Specificity

Expressed in the brain and the retina. Expressed strongly in rod and cone cells (at protein level).
Target Research Area

Others
Target Synonyms

D14S46E; Neural retina-specific leucine zipper protein; Neural retinal specific leucine zipper; NRL; NRL MAF; NRL_HUMAN; RP27
Target Background

This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases.

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Recombinant Human Neural retina-specific leucine zipper protein (NRL)

Specifications

Immunogen Information

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