Recombinant Human Glutamine–tRNA ligase (QARS)

Uniprot Id

P47897

Target Species

Human

Target Name

QARS1

Target Full Name

Glutamine--tRNA ligase

Target Function

Glutamine--tRNA ligase. Plays a critical role in brain development.

Target Involvement

Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)

Target Subcellular Location

Cytoplasm, cytosol. Cytoplasm.

Target Protein Families

Class-I aminoacyl-tRNA synthetase family

Target Tissue Specificity

Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate.

Target Synonyms

GlnRS; Glutamine tRNA ligase; Glutamine tRNA synthetase; Glutamine--tRNA ligase; Glutaminyl tRNA ligase; Glutaminyl tRNA synthetase; Glutaminyl-tRNA synthetase; PRO2195; QARS; SYQ_HUMAN

Target Background

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine (gln), glutamic acid (glu), and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase (QARS) is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNA(Gln) is formed by transamidation of the misacylated Glu-tRNA(Gln). Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Alternative splicing results in multiple transcript variants.