Recombinant Human Microtubule-associated protein 1B (MAP1B), Truncated

Uniprot Id

P46821

Target Species

Human

Target Name

MAP1B

Target Full Name

Microtubule-associated protein 1B

Target Function

Facilitates tyrosination of alpha-tubulin in neuronal microtubules. Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

Target Subcellular Location

Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, synapse. Cell projection, dendritic spine.; [MAP1 light chain LC1]: Cytoplasm.

Target Protein Families

MAP1 family

Target Synonyms

FUTSCH; LC1; MAP-1B; MAP1 light chain LC1; Map1b; MAP1B_HUMAN; MAP5; Microtubule associated protein 1B; Mtap1b; Mtap5

Target Background

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1B heavy chain and LC1 light chain. Gene knockout studies of the mouse microtubule-associated protein 1B gene suggested an important role in development and function of the nervous system.