Recombinant Human Short transient receptor potential channel 1 (TRPC1)

Uniprot Id

P48995

Target Species

Human

Target Name

TRPC1

Target Full Name

Short transient receptor potential channel 1

Target Function

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC1 sub-subfamily

Target Tissue Specificity

Seems to be ubiquitous.

Target Synonyms

HTRP 1; HTRP1; MGC133334; MGC133335; Mtrp1; Short transient receptor potential channel 1; Transient receptor potential canonical 1; Transient receptor potential cation channel subfamily C member 1; Transient receptor potential channel 1; Transient receptor protein 1; TRP 1; TRP 1 protein; Trp related protein 1; TRP-1; TRP1; TRP1 protein; TrpC1; Trpc1 transient receptor potential cation channel subfamily C member 1; TRPC1_HUMAN; Trrp1

Target Background

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene.