Recombinant Human Protein-glutamine gamma-glutamyltransferase K (TGM1), Truncated

Uniprot Id

P22735

Target Species

Human

Target Name

TGM1

Target Full Name

Protein-glutamine gamma-glutamyltransferase K

Target Function

Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum. Involved in cell proliferation.

Target Involvement

Ichthyosis, congenital, autosomal recessive 1 (ARCI1)

Target Subcellular Location

Membrane; Lipid-anchor.

Target Protein Families

Transglutaminase superfamily, Transglutaminase family

Target Synonyms

ARCI1; Epidermal TGase; ICR2; KTG; LI; LI1; Protein glutamine gamma glutamyltransferase K; Protein-glutamine gamma-glutamyltransferase K; TG(K); TGase 1; TGASE; TGase K; TGase-1; TGK; TGM1; TGM1_HUMAN; Transglutaminase 1 (K polypeptide epidermal type I; protein glutamine gamma glutamyltransferase); Transglutaminase 1; Transglutaminase K; Transglutaminase; keratinocyte; Transglutaminase-1

Target Background

The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3' UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE).