Recombinant Human Amiloride-sensitive amine oxidase [copper-containing] (ABP1)

Uniprot Id

P19801

Target Species

Human

Target Name

AOC1

Target Full Name

Diamine oxidase [copper-containing]

Target Function

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.

Target Subcellular Location

Secreted, extracellular space.

Target Protein Families

Copper/topaquinone oxidase family

Target Tissue Specificity

Placenta and kidney.

Target Synonyms

ABP; Abp1; ABP1_HUMAN; Amiloride binding protein 1 (amine oxidase (copper containing)); Amiloride binding protein 1; Amiloride binding protein; Amiloride sensitive amine oxidase; Amiloride-binding protein; Amiloride-sensitive amine oxidase [copper-containing]; Amine oxidase copper domain containing protein 1; AOC1; DAO; DAO1; Diamine oxidase; Histaminase; KAO; Kidney amine oxidase

Target Background

This gene encodes a metal-binding membrane glycoprotein that oxidatively deaminates putrescine, histamine, and related compounds. The encoded protein is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.