Recombinant Human Pancreatic triacylglycerol lipase (PNLIP)

Uniprot Id

P16233

Target Species

Human

Target Name

PNLIP

Target Full Name

Pancreatic triacylglycerol lipase

Target Function

Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.

Target Involvement

Pancreatic lipase deficiency (PNLIPD)

Target Subcellular Location

Secreted.

Target Protein Families

AB hydrolase superfamily, Lipase family

Target Synonyms

lipase, pancreatic; LIPP_HUMAN; Pancreatic lipase; Pancreatic triacylglycerol lipase; PL; PNLIP; PNLIPD; PTL; Triacylglycerol acylhydrolase

Target Background

This gene encodes a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.