Recombinant Human Cyclin-dependent kinase 11B (CDK11B)

Uniprot Id

P21127

Target Species

Human

Target Name

CDK11B

Target Full Name

Cyclin-dependent kinase 11B

Target Function

Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily

Target Tissue Specificity

Expressed ubiquitously. Some evidence of isoform-specific tissue distribution.

Target Synonyms

CDK11B; CDC2L1; CDK11; PITSLREA; PK58; Cyclin-dependent kinase 11B; EC 2.7.11.22; Cell division cycle 2-like protein kinase 1; CLK-1; Cell division protein kinase 11B; Galactosyltransferase-associated protein kinase p58/GTA; PITSLRE serine/threonine-protein kinase CDC2L1; p58 CLK-1

Target Background

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants.