Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (HPGD)

Cat.No	ACP24081	Target Name	HPGD
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-266	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP24081

Target Name

HPGD

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-266

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P15428

Background Information

Uniprot Id

P15428
Target Species

Human
Target Name

HPGD
Target Full Name

15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Target Function

Primary enzyme catalyzing the conversion of hydroxylated arachidonic acid species to their corresponding oxidized metabolites (Probable). Prostaglandin inactivation, catalyzes the first step in the catabolic pathway of the prostaglandins. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Converts 11(R)-HETE to 11-oxo-5,8,12,14-(Z,Z,E,Z)-eicosatetraenoic acid (ETE). Has hydroxylated docosahexaenoic acid metabolites as substrates. Converts resolvins E1, D1 and D2 to their oxo products which represents a mode of resolvins inactivation and stabilizes their anti-inflammatory actions.
Target Involvement

Hypertrophic osteoarthropathy, primary, autosomal recessive, 1 (PHOAR1); Cranioosteoarthropathy (COA); Isolated congenital nail clubbing (ICNC)
Target Subcellular Location

Cytoplasm.
Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity

Detected in colon epithelium (at protein level).
Target Synonyms

15 hydroxyprostaglandin dehydrogenase [NAD+]; 15 PGDH; 15-hydroxyprostaglandin dehydrogenase [NAD+]; 15-PGDH; 15PGDH; Hpgd; Hydroxyprostaglandin dehydrogenase 15 (NAD); NAD+ dependent 15 hydroxyprostaglandin dehydrogenase; OTTHUMP00000218960; OTTHUMP00000219016; OTTHUMP00000219018; PGDH; PGDH_HUMAN; PGDH1; PHOAR1; Prostaglandin dehydrogenase 1; SDR36C1; Short chain dehydrogenase/reductase family 36C member 1
Target Background

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (HPGD)

Specifications

Immunogen Information

Inquire Recombinant Human 15-hydroxyprostaglandin dehydrogenase [NAD (+)] (HPGD) Now

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