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| Cat.No | ACP24109 | Target Name | TPH1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-444 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P17752 |
|---|
Uniprot Id
P17752
Target Species
Human
Target Name
TPH1
Target Full Name
Tryptophan 5-hydroxylase 1
Target Function
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
Target Protein Families
Biopterin-dependent aromatic amino acid hydroxylase family
Target Tissue Specificity
[Isoform 2]: Seems to be less widely expressed than isoform 1.
Target Synonyms
Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1
Target Background
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
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