Recombinant Human 28S ribosomal protein S11, mitochondrial (MRPS11)

Uniprot Id

P82912

Target Species

Human

Target Name

MRPS11

Target Full Name

Small ribosomal subunit protein uS11m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uS11 family

Target Synonyms

28S ribosomal protein S11; 28S ribosomal protein S11 mitochondrial; 28S ribosomal protein S11, mitochondrial precursor; Cervical cancer proto oncogene 2 protein; Cervical cancer proto-oncogene 2 protein; HCC 2; HCC-2; mitochondrial; Mitochondrial ribosomal protein S11; MRP S11; MRP-S11; MRPS11; RPMS11; RT11_HUMAN; S11mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene.