Recombinant Human Casein kinase I isoform gamma-2 (CSNK1G2)

Uniprot Id

P78368

Target Species

Human

Target Name

CSNK1G2

Target Full Name

Casein kinase I isoform gamma-2

Target Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Target Subcellular Location

Cytoplasm, cell cortex. Cytoplasm.

Target Protein Families

Protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily

Target Tissue Specificity

Testis.

Target Synonyms

Casein kinase 1; gamma 2; Casein kinase I isoform gamma 2; Casein kinase I isoform gamma-2; CK1g2; CKI gamma 2; CKI-gamma 2; CSNK1G 2; Csnk1g2; KC1G2_HUMAN

Target Background

Enables protein serine/threonine kinase activity. Involved in peptidyl-serine phosphorylation. Located in membrane.