Recombinant Human Pituitary homeobox 1 (PITX1)

Uniprot Id

P78337

Target Species

Human

Target Name

PITX1

Target Full Name

Pituitary homeobox 1

Target Function

Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb.

Target Involvement

Clubfoot, congenital, with or without deficiency of long bones and/or mirror-image polydactyly (CCF); Liebenberg syndrome (LBNBG)

Target Subcellular Location

Nucleus.

Target Protein Families

Paired homeobox family, Bicoid subfamily

Target Synonyms

BFT; CCF; Hindlimb expressed homeobox protein backfoot ; Hindlimb-expressed homeobox protein backfoot; Homeobox protein PITX1; LBNBG; Paired like homeodomain 1; Paired like homeodomain transcription factor 1; Paired-like homeodomain transcription factor 1; Pituitary homeo box 1; Pituitary homeobox 1; Pituitary otx related factor; Pitx1; PITX1_HUMAN; POTX; PTX1

Target Background

This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.