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The antibody against SNX15 was raised in rabbit using the Recombinant Human Sorting nexin-15 protein (144-321AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SNX15 was raised in rabbit using the Recombinant Human Sorting nexin-15 protein (144-321AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using SNX15 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human lung tissue using SNX15 Antibody at dilution of 1:1002
Immunofluorescent analysis of HepG2 cells using SNX15 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-11568A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SNX15 |
| Target Synonyms | Clone iota unknown protein antibody; HSAF001435 antibody; SNX 15 antibody; SNX15 antibody; SNX15_HUMAN antibody; Sorting nexin 15 antibody; Sorting nexin-15 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sorting nexin-15 protein (144-321AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NRS6 |
Uniprot Id
Q9NRS6
Target Species
Human
Target Name
SNX15
Target Full Name
Sorting nexin-15
Target Function
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN.
Target Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families
Sorting nexin family
Target Tissue Specificity
Widely expressed.
Target Synonyms
Clone iota unknown protein; HSAF001435; SNX 15; SNX15; SNX15_HUMAN; Sorting nexin 15; Sorting nexin-15
Target Background
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene.
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