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The antibody against IL17C was raised in rabbit using the Synthetic peptide from Human protein at AA range: 81-130 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against IL17C was raised in rabbit using the Synthetic peptide from Human protein at AA range: 81-130 as the immunogen. This antibody exists as a non-conjugated antibody. The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:200
Immunohistochemical analysis of paraffin-embedded human-colon, antibody was diluted at 1:2002
Immunohistochemical analysis of paraffin-embedded human-pancreas, antibody was diluted at 1:2003
| Cat.No | ADC-12980A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | IL17C |
| Form | Liquid | Species Reactivity | Human |
| Storage Buffer | PH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol., PBS | Purification Method | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthetic peptide from Human protein at AA range: 81-130 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9P0M4 |
Uniprot Id
Q9P0M4
Target Species
Human
Target Name
IL17C
Target Full Name
Interleukin-17C
Target Function
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
Target Subcellular Location
Secreted.
Target Protein Families
IL-17 family
Target Synonyms
CX2 ; Cytokine CX2; IL 17C; IL 21 ; IL-17C; IL17C; IL17C_HUMAN; Interleukin 17C; Interleukin-17C; MGC126884 ; MGC138401
Target Background
The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells.
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