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The antibody against SLC6A3 was raised in rabbit using the Recombinant Human Sodium-dependent dopamine transporter protein (161-237AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against SLC6A3 was raised in rabbit using the Recombinant Human Sodium-dependent dopamine transporter protein (161-237AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-13906A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SLC6A3 |
| Target Synonyms | member 3 antibody; Solute carrier family 6 (neurotransmitter transporter), member 3 antibody; Solute carrier family 6 member 3 antibody; Variable number tandem repeat (VNTR) antibody | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Sodium-dependent dopamine transporter protein (161-237AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q01959 |
Uniprot Id
Q01959
Target Species
Human
Target Name
SLC6A3
Target Full Name
Sodium-dependent dopamine transporter
Target Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling.
Target Involvement
Parkinsonism-dystonia infantile (PKDYS)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Cell projection, neuron projection.
Target Protein Families
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A3 subfamily
Target Tissue Specificity
Highly expressed in substantia nigra.
Target Synonyms
DAT; DAT1; PKDYS; PKDYS1; Dopamine Transporter/SLC6A3
Target Background
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
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