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The antibody against ACSF3 was raised in rabbit using the Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against ACSF3 was raised in rabbit using the Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human ovarian cancer using ACSF3 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human prostate cancer using ACSF3 Antibody at dilution of 1:1002
| Cat.No | ADC-15393A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ACSF3 |
| Target Synonyms | ACSF3 antibody; PSEC0197Malonate--CoA ligase ACSF3 antibody; mitochondrial antibody; EC 6.2.1.n3 antibody; Acyl-CoA synthetase family member 3 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Acyl-CoA synthetase family member 3, mitochondrial protein (365-484AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q4G176 |
Uniprot Id
Q4G176
Target Species
Human
Target Name
ACSF3
Target Full Name
Malonate--CoA ligase ACSF3, mitochondrial
Target Function
Catalyzes the initial reaction in intramitochondrial fatty acid synthesis, by activating malonate and methylmalonate, but not acetate, into their respective CoA thioester. May have some preference toward very-long-chain substrates.
Target Involvement
Combined malonic and methylmalonic aciduria (CMAMMA)
Target Subcellular Location
Mitochondrion.
Target Protein Families
ATP-dependent AMP-binding enzyme family
Target Synonyms
ACSF3; PSEC0197Malonate--CoA ligase ACSF3; mitochondrial; EC 6.2.1.n3; Acyl-CoA synthetase family member 3
Target Background
This gene encodes a member of the acyl-CoA synthetase family of enzymes that activate fatty acids by catalyzing the formation of a thioester linkage between fatty acids and coenzyme A. The encoded protein is localized to mitochondria, has high specificity for malonate and methylmalonate and possesses malonyl-CoA synthetase activity. Mutations in this gene are a cause of combined malonic and methylmalonic aciduria. Alternatively spliced transcript variants have been observed for this gene.
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