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The antibody against RTEL1 was raised in rabbit using the Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against RTEL1 was raised in rabbit using the Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-15727A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RTEL1 |
| Target Synonyms | RTEL1 antibody; C20orf41 antibody; KIAA1088 antibody; NHLRegulator of telomere elongation helicase 1 antibody; EC 3.6.4.12 antibody; Novel helicase-like antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Regulator of telomere elongation helicase 1 protein (975-1219AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9NZ71 |
Uniprot Id
Q9NZ71
Target Species
Human
Target Name
RTEL1
Target Full Name
Regulator of telomere elongation helicase 1
Target Function
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.
Target Involvement
Dyskeratosis congenita, autosomal recessive, 5 (DKCB5); Dyskeratosis congenita, autosomal dominant, 4 (DKCA4); Pulmonary fibrosis, and/or bone marrow failure, telomere-related, 3 (PFBMFT3)
Target Subcellular Location
Nucleus.
Target Protein Families
Helicase family, RAD3/XPD subfamily
Target Synonyms
RTEL1; C20orf41; KIAA1088; NHLRegulator of telomere elongation helicase 1; EC 3.6.4.12; Novel helicase-like
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