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The antibody against LEO1 was raised in rabbit using the Peptide sequence from Human RNA polymerase-associated protein LEO1 protein (2-24AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
The antibody against LEO1 was raised in rabbit using the Peptide sequence from Human RNA polymerase-associated protein LEO1 protein (2-24AA) as the immunogen. This antibody exists as a fitc conjugated isotype IgG, purified by protein G with a purity greater than 95%.
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| Cat.No | ADC-01422A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | LEO1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | FITC conjugated |
| Storage | Upon receipt |
| Immunogen Description | Peptide sequence from Human RNA polymerase-associated protein LEO1 protein (2-24AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8WVC0 |
Uniprot Id
Q8WVC0
Target Species
Human
Target Name
LEO1
Target Full Name
RNA polymerase-associated protein LEO1
Target Function
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Involved in polyadenylation of mRNA precursors. Connects PAF1C to Wnt signaling.
Target Subcellular Location
Nucleus.
Target Protein Families
LEO1 family
Target Tissue Specificity
Highly expressed in skeletal muscle and heart. Weakly expressed in placenta and liver.
Target Synonyms
Gm185; LEO1; LEO1_HUMAN; LOC123439; Paf1/RNA polymerase II complex component; Replicative senescence down regulated leo1 like protein ; Replicative senescence down-regulated leo1-like protein; Replicative senescence downregulated leo1 like ; RNA polymerase associated protein LEO1; RNA polymerase-associated protein LEO1; Senescence downregulated leo1 like
Target Background
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).
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