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The antibody against CD180 was raised in rabbit using the Recombinant Human CD180 antigen protein (24-220AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against CD180 was raised in rabbit using the Recombinant Human CD180 antigen protein (24-220AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
$299.00
Immunohistochemistry of paraffin-embedded human tonsil tissue using CD180 Antibody at dilution of 1:1002
| Cat.No | ADC-16458A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD180 |
| Target Synonyms | 105kDa antibody; MGC126233 antibody; MGC126234 antibody; Radioprotective 105 kDa protein antibody; RP105 antibody, radioprotective | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human CD180 antigen protein (24-220AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99467 |
Uniprot Id
Q99467
Target Species
Human
Target Name
CD180
Target Full Name
CD180 antigen
Target Function
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Toll-like receptor family
Target Tissue Specificity
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Target Synonyms
CD180; CD180 antigen; CD180_HUMAN; F630107B15; LY64; Ly78; Lymphocyte antigen 64; lymphocyte antigen 64 radioprotective 105kDa; lymphocyte antigen-64, radioprotective, 105kDa; MGC126233; MGC126234; Radioprotective 105 kDa protein; RP105
Target Background
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria.
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