Rabbit anti-Human SCYL1 Polyclonal Antibody

Uniprot Id

Q96KG9

Target Species

Human

Target Name

SCYL1

Target Full Name

N-terminal kinase-like protein

Target Function

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology. Has no detectable kinase activity in vitro.; Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region.

Target Involvement

Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21)

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; [Isoform 6]: Nucleus.

Target Protein Families

Protein kinase superfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

Coated vesicle associated kinase of 90 kDa; Coated vesicle-associated kinase of 90 kDa; CVAK90; GKLP; HT019; Likely ortholog of mouse N terminal kinase like protein ; MGC78454; N terminal kinase like; N terminal kinase like protein; N-terminal kinase-like protein; NKTL; NTKL; NTKL_HUMAN; NTKLBP1; P105; SCY L1; SCY1 like 1; SCY1 like 1 protein 1; SCY1-like protein 1; SCYL 1; Scyl1; SCYL1BP1; TAPK; TEIF; Telomerase regulation associated protein; Telomerase regulation-associated protein; Telomerase transcriptional element interacting factor ; Telomerase transcriptional element-interacting factor; Teratoma associated tyrosine kinase ; Teratoma-associated tyrosine kinase; TRAP

Target Background

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene.